Polycythemia Vera (PV) Clinical Knowledge Check
TEST YOUR KNOWLEDGE OF POLYCYTHEMIA VERA WITH THIS TEN QUESTION QUIZ
Instructions
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Results summary at the end
In polycythemia vera, JAK2 V617F allele burden >50% has been most consistently associated with:
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What is the principal therapeutic reason for maintaining hematocrit <45% in PV?
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Out of the following symptoms, which has been ranked by patients as most severe?
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Which of the following have been shown to negatively impact patients with PV?
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What known symptoms of PV are patients least likely to attribute to their PV?
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Which circulating hormone is the central regulator of systemic iron homeostasis by controlling intestinal iron absorption and iron release from macrophages and hepatocytes?
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Which feature of therapeutic phlebotomy contributes to worsening symptoms in PV?
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PV patients being treated with cytoreductive therapy can experience which of the following?
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Iron deficiency is associated with which of the following?
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Patients with PV often present with iron deficiency without anemia. Which of the following mechanisms contribute to this paradox?
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References
- Moliterno et al. JAK2V617F allele burden in polycythemia vera: burden of proof. Blood 2023; 141 (16): 1934–1942.
- Tefferi and Barbui. Polycythemia vera: 2024 update on diagnosis, risk-stratification, and management. Am J Hematol. 2023;98:1465–1487.
- Mesa et al. Myeloproliferative neoplasms (MPNs) have a significant impact on patients’ overall health and productivity: the MPN Landmark survey. BMC Cancer 2016; 16:167.
- Ginzburg et al. Dysregulated iron metabolism in polycythemia vera: etiology and consequences.Leukemia 2018; 32: 2105–2116.
- Kuykendall et al. Contemporary Challenges in Polycythemia Vera Management From the Perspective of Patients and Physicians, Clinical Lymphoma Myeloma and Leukemia, 2024; 24, 8, 512-522.
- Grunwald et al. Symptom Burden and Blood Counts in Patients With Polycythemia Vera in the United States: An Analysis From the REVEAL Study. Clin Lymphoma Myeloma Leuk. 2019; 19(9): 579–584.
- Camaschella. Iron-Deficiency Anemia. N Engl J Med 2015;372:1832-43.